Alzheimer’s disease has no cure. There are, however, five drugs—known and ap

游客2024-10-09 61

问题 Alzheimer’s disease has no cure. There are, however, five drugs—known and approved—that can slow down the development of its symptoms. The earlier such drugs are administered, the better. Unfortunately, the disease is usually first noticed when people complain to their doctors of memory problems. That is normally too late for the drugs to do much good. A simple and reliable test for Alzheimer’s that can be administered to everybody over the age of about 65 , before memory-loss sets in, would therefore be useful.
Theo Luider, of the Erasmus University Medical Centre in Rotterdam, and his colleagues think they have found one—but it works only in women. They made their discovery, just reported in the Journal of Proteome Research, by tapping into a long-term, continuing study that started in 1995 with 1, 077 non-demented and otherwise healthy people aged between 60 and 90. At the beginning of the project, and subsequently during the periods 1997-99 and 2002-04, participants were brought in for a battery of neurological(神经学的)and cognitive investigations, physical examinations, brain imaging and blood tests.
During the first ten years of the study, 43 of the volunteers developed Alzheimer’s disease. When Dr. Luider compared blood samples from these people with samples from 43 of their fellow volunteers, matched for sex and age, who had remained Alzheimer’s-free, he found something startling. Levels of a substance called pregnancy zone protein had been unusually high, even before their symptoms appeared, in some of those who went on to develop Alzheimer’s disease.
Those "some" , it turned out, were all women. On average, levels of pregnancy zone protein in those women who went on to develop Alzheimer’s were almost 60% higher than those of women who did not. In men, levels of the protein were the same for both.
The reason for this curious result seems to be that the brain plaques(斑块)associated with Alzheimer’s disease are themselves turning out pregnancy zone protein. Certainly, when Dr. Luider applied a chemical stain specific to that protein to the plaques of dead Alzheimer’s patients he found the protein present in them.
Confusingly, though, it was there in the plaques of both sexes. Presumably, female cells(and therefore the plaques of female brains)make more of it than male cells do. But that remains to be proved. Whatever the reason, however, this result means that women, at least, may soon be able to tell whether and when they are at risk of Alzheimer’s—and thus do something about it before they start losing their minds. [br] The passage is mainly about______.

选项 A、the development stages of Alzheimer’s disease
B、the pregnancy zone protein
C、a new discovery concerning Alzheimer’s disease
D、patients of Alzheimer’s disease

答案 C

解析主旨题。本文开篇第一段指出阿尔茨海默病是难以治愈和难以发现的，并指出阿尔茨海默病预防治疗的一个重要环节，即在患者记忆力减退前诊断出该症状；接下来，第二到四段详述了关于阿尔茨海默病的一项新发现——女性阿尔茨海默病患者体内的妊娠区带蛋白质含量比未患此病的女性高很多，甚至在还未患上阿尔茨海默病之前，这些女性患者体内的妊娠区带蛋白质的含量已经相当的高；第五段分析了出现这一现象的原因；最后一段分析了该实验未解决的疑问以及肯定了这一新发现的意义。综上所述，本文都是围绕“阿尔茨海默病领域的一项新发现”展开的，故[C]为正确答案。

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