By the middle of the twentieth century, painters and sculptors in the United Sta

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问题 By the middle of the twentieth century, painters and sculptors in the United States_______________________. (开始在世界范围内对艺术发生重大影响)

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答案 had begun to exert a great world wide influence over art

解析 “发挥影响”用动词短语“exert (have) influence over...”比较合适。注意因为状语是介词“by”引导，表示“到……(时间)为止”，所以主句时态用过去完成时。

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